SUPRABIOIN

Permanent URI for this collectionhttps://hdl.handle.net/10347/46463

SUPRABIOIN (Química Bioinorgánica e Supramolecular) é un grupo de investigación recoñecido como de excelencia competitiva. Investigación en química supramolecular, helicatos cluster, novas rotas de síntese de complexos e estudo da actividade catalítica dos complexos metálicos e a determinación dos mecanismos de reacción destes procesos.

Este grupo foi impulsor da Rede MetalBIO (Rede galega de investigación de ións metálicos en sistemas biolóxicos).

SUPRABIOIN é membro da rede europea Perspect-H2O (Supramolecular Photocatalytic Water Splitting) e das redes de excelencia MetalBIO (Red de iones metálicos en sistemas biológicos), MetDrugs (Metals in Therapy and Diagnosis) e H2BioCatO2(Complejos metálicos biomiméticos: utilización de hidrógeno, oxígeno y dióxido de carbono).

A actividade de innovación e investigación do ámbito docente do grupo recóllese no portal de CienciaNOSA, Grupo de innovación docente en didáctica e divulgación científica. En funil.gal podes acceder a laboratorio visual de química desenvolto dende este grupo.

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Now showing 1 - 20 of 51

A Dinuclear Copper(II) Complex Electrochemically Obtained via the Endogenous Hydroxylation of a Carbamate Schiff Base Ligand: Synthesis, Structure and Catalase Activity
(MDPI, 2024-02-10) Fernández-Fariña, Sandra; Velo Heleno, Isabel; Rodríguez Silva, Laura; Maneiro Maneiro, Marcelino; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
In the present work, we report a neutral dinuclear copper(II) complex, [Cu2(L1)(OH)], derived from a new [N,O] donor Schiff base ligand L1 that was formed after the endogenous hydroxylation of an initial carbamate Schiff base H2L coordinated with copper ions in an electrochemical cell. The copper(II) complex has been fully characterized using different techniques, including X-ray diffraction. Direct current (DC) magnetic susceptibility measurements were also performed at variable temperatures, showing evidence of antiferromagnetic behavior. Its catalase-like activity was also tested, demonstrating that this activity is affected by temperature.
Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects
(MDPI, 2024-02-22) Rouco Méndez, Lara; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; Fernández-Fariña, Sandra; González Noya, Ana María; Martínez Calvo, Miguel; Pedrido Castiñeiras, Rosa; Rodríguez Silva, Laura; Maneiro Maneiro, Marcelino; Universidade de Santiago de Compostela. Departamento de Química Inorgánica; Universidade de Santiago de Compostela. Departamento de Fisioloxía; Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Manganosalen complexes are a class of catalytic antioxidants with beneficial effects against different neurological disorders according to various in vitro and in vivo studies. The interest in the factors that determine their antioxidant activity is based on the fact that they are key to achieving more efficient models. In this work, we report a set of new manganosalen complexes, thoroughly characterized in the solid state and in solution by different techniques. The chelating Schiff base ligands used were prepared from condensation of different substituted hydroxybenzaldehydes with 1,2-diaminoethane and 1,3-diaminopropane. The antioxidant activity of the new models was tested through superoxide dismutase and catalase probes in conjunction with the studies about their neuroprotective effects in human SH-SY5Y neuroblastoma cells in an oxidative stress model. The ability to scavenge excess reactive oxygen species (ROS) varied depending on the manganosalen models, which also yielded different improvements in cell survival. An assessment of the different factors that affect the oxidant activity for these complexes, and others previously reported, revealed the major influence of the structural factors versus the redox properties of the manganosalen complexes.
Endeavor toward Redox-Responsive Transition Metal Contrast Agents Based on the Cross-Bridge Cyclam Platform
(American Chemical Society, 2024-01-10) Uzal-Varela, Rocío; Rodríguez-Rodríguez, Aurora; Lalli, Daniela; Valencia, Laura; Maneiro Maneiro, Marcelino; Botta, Mauro; Iglesias, Emilia; Esteban-Gómez, David; Angelovski, Goran; Platas-Iglesias, Carlos; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
We present the synthesis and characterization of a series of Mn(III), Co(III), and Ni(II) complexes with cross-bridge cyclam derivatives (CB-cyclam = 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane) containing acetamide or acetic acid pendant arms. The X-ray structures of [Ni(CB-TE2AM)]Cl2·2H2O and [Mn(CBTE1AM)(OH)](PF6)2 evidence the octahedral coordination of the ligands around the Ni(II) and Mn(III) metal ions, with a terminal hydroxide ligand being coordinated to Mn(III). Cyclic voltammetry studies on solutions of the [Mn(CBTE1AM)(OH)]2+ and [Mn(CB-TE1A)(OH)]+ complexes (0.15 M NaCl) show an intricate redox behavior with waves due to the MnIII/MnIV and MnII/MnIII pairs. The Co(III) and Ni(II) complexes with CB-TE2A and CB-TE2AM show quasireversible features due to the CoIII/CoII or NiII/NiIII pairs. The [Co(CBTE2AM)]3+ complex is readily reduced by dithionite in aqueous solution, as evidenced by 1H NMR studies, but does not react with ascorbate. The [Mn(CBTE1A)(OH)]+ complex is however reduced very quickly by ascorbate following a simple kinetic scheme (k0 = k1[AH−], where [AH−] is the ascorbate concentration and k1 = 628 ± 7 M−1 s−1). The reduction of the Mn(III) complex to Mn(II) by ascorbate provokes complex dissociation, as demonstrated by 1H nuclear magnetic relaxation dispersion studies. The [Ni(CB-TE2AM)]2+ complex shows significant chemical exchange saturation transfer effects upon saturation of the amide proton signals at 71 and 3 ppm with respect to the bulk water signal.
Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation
(MDPI, 2024-02-04) Barreiro Sisto, Uxía; Fernández-Fariña, Sandra; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Maneiro Maneiro, Marcelino; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
This review aims to analyze the emerging number of studies on biological media that describe the unexpected effects of different natural bioactive antioxidants. Hormetic effects, with a biphasic response depending on the dose, or activities that are apparently non-dose-dependent, have been described for compounds such as resveratrol, curcumin, ferulic acid or linoleic acid, among others. The analysis of the reported studies confirms the incidence of these types of effects, which should be taken into account by researchers, discarding initial interpretations of imprecise methodologies or measurements. The incidence of these types of effects should enhance research into the different mechanisms of action, particularly those studied in the field of basic research, that will help us understand the causes of these unusual behaviors, depending on the dose, such as the inactivation of the signaling pathways of the immune defense system. Antioxidative and anti-inflammatory activities in biological media should be addressed in ways that go beyond a mere statistical approach. In this work, some of the research pathways that may explain the understanding of these activities are revised, paying special attention to the ability of the selected bioactive compounds (curcumin, resveratrol, ferulic acid and linoleic acid) to form metal complexes and the activity of these complexes in biological media.
Application of the aza-Wittig reaction for the synthesis of carboranyl Schiff bases, benzothiazoles and benzoselenazolines
(Royal Society of Chemistry, 2025-01-09) Crujeiras Barral, Pablo; Vázquez Carballo, Irene; Sousa Pedrares, Antonio; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
The aza-Wittig reaction was successfully applied to the synthesis of carboranyl-imines, which are difficult to obtain by classical methods. A variety of functionalized carboranyl Schiff bases was obtained proving the great scope of the methodology. All compounds were fully characterized, including the solid-state structures of six of them. The aza-Wittig reaction was modified to permit the synthesis in one step of carboranyl-benzothiazole and carboranyl-benzoselenazoline derivatives. The stability studies show that the carboranyl-imines and benzothiazole promote deboronation to the nido-derivatives, which is achieved by simple reaction with methanol or protic solvents. The structures of the nido-derivatives were also studied by X-ray diffraction. In contrast, the saturated derivatives, amine and benzoselenazoline, do not promote deboronation and are stable in protic solvents.
Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates
(MDPI, 2023-01-23) Fernández-Fariña, Sandra; Velo Heleno, Isabel; Carballido, Rocío; Martínez-Calvo, Miguel; Barcia Vieitez, Ramiro; Palacios, Òscar; Capdevila, Mercè; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Universidade de Santiago de Compostela. Departamento de Química Inorgánica; Universidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Molecular
The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within metallosupramolecular chemistry. Herein, we report three zinc helicates derived from a family of bisthiosemicarbazone ligands with different terminal groups, Zn2(LMe)2∙2H2O 1, Zn2(LPh)2∙2H2O 2 and Zn2(LPhNO2)2 3, obtained by an electrochemical methodology. These helicates have been fully characterized by different techniques, including X-ray diffraction. Biological studies of the zinc(II) helicates such as toxicity assays with erythrocytes and interaction studies with proteins and oligonucleotides were performed, demonstrating in all cases low toxicity and an absence of covalent interaction with the proteins and oligonucleotides. The in vitro cytotoxicity of the helicates was tested against MCF-7 (human breast carcinoma), A2780 (human ovarian carcinoma cells), NCI-H460 (human lung carcinoma cells) and MRC-5 (normal human lung fibroblasts), comparing the IC50 values with cisplatin. We will try to demonstrate if the terminal substituent of the ligand precursor exerts any effect in toxicity or in the antitumor activity of the zinc helicates
Schiff Bases Functionalized with T-Butyl Groups as Adequate Ligands to Extended Assembly of Cu(II) Helicates
(MDPI, 2023-05-12) Fernández-Fariña, Sandra; Velo Heleno, Isabel; Martínez-Calvo, Miguel; Maneiro Maneiro, Marcelino; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
The study of the inherent factors that influence the isolation of one type of metallosupramolecular architecture over another is one of the main objectives in the field of Metallosupramolecular Chemistry. In this work, we report two new neutral copper(II) helicates, [Cu2(L1)2]·4CH3CN and [Cu2(L2)2]·CH3CN, obtained by means of an electrochemical methodology and derived from two Schiff-based strands functionalized with ortho and para-t-butyl groups on the aromatic surface. These small modifications let us explore the relationship between the ligand design and the structure of the extended metallosupramolecular architecture. The magnetic properties of the Cu(II) helicates were explored by Electron Paramagnetic Resonance (EPR) spectroscopy and Direct Current (DC) magnetic susceptibility measurements
Electrochemical Conversion of 5-Hydroxymethylfurfural to 2,5-Furandicarboxaldehyde Using Mn(III)–Schiff Base Catalysts
(MDPI, 2025-02-01) Barreiro Sisto, Uxía; Fernández-Fariña, Sandra; Fernández García, María Isabel; González Noya, Ana María; Velo Heleno, Isabel; Maneiro Maneiro, Marcelino; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
2,5-furandicarboxaldehyde (DFF) is one of the most promising biomass-based building blocks for the synthesis of biobased polymers. DFF can be obtained from 5-hydroxymethylfurfural (HMF), a fructose derivate, and it is a key molecule in the sequence of reactions of furan chemistry to develop biobased plastics. In this frame, four manganese(III)–Schiff base complexes 1–4 have been obtained. The general formula for the complexes, MnLn(OCN)(H2O/CH3OH)m (Ln being the Schiff base ligands L1–L4, formed as the result of the condensation of different substituted hydroxybenzaldehydes with diverse diamines, and m = 1–3), has been confirmed by characterization through different analytical and spectroscopic techniques. X-ray crystallographic studies for 1 and 2 showed tetragonally distorted octahedral structures, where the Schiff base was placed in the equatorial coordination positions of the Mn(III) ion. Complexes 1 and 2 behaved as efficient catalysts in the oxidation of HMF to DFF in an electrolytic reaction at pH 8.5, with phosphate buffer at room temperature, with conversion rates of 70–80%. On the other hand, complexes 3 and 4, where the axial position was sterically less accessible, yielded only an 11% conversion of HMF to DFF. The results indicate that a correct selection of metal complexes allows the development of a new efficient way to obtain DFF.
Effect of the Metal Ion on the Enantioselectivity and Linkage Isomerization of Thiosemicarbazone Helicates
(Wiley-VCH Verlag GmbH & Co. KGaA, 2017) Romero Castro, María José; Suárez, Vanesa; Fernández-Fariña, Sandra; Maneiro Maneiro, Marcelino; Martínez Núñez, Emilio; Zaragoza Vérez, Guillermo; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Universidade de Santiago de Compostela. Departamento de Química Inorgánica; Universidade de Santiago de Compostela. Departamento de Química Física
The effect of the metal ion and ligand design on the enantioselectivity and linkage isomerization of neutral cobalt and zinc bisthiosemicarbazone metallohelicates has been investigated in this work. The electrochemical synthesis has afforded the enantioselective formation of chirally pure cobalt helicates, and the Lambda-Lambda isomer of a single enantiomer has been crystallized as only product for the cobalt methylsubstituted thiosemicarbazone helicate. Interestingly linkage isomers have been formed from zinc ethyl-substituted thiosemicarbazone helicate enantiomers for the first time. The co-existence of these isomers has been evaluated from the point of view of both experimental results and computational calculations.
Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes
(Springer Nature, 2016-02-12) Carter, R.; Westhorpe, A.; Romero Castro, María José; Habtemariam, A.; Gallevo, C. R.; Bark, Y.; Menezes, N.; Sadler, P. J.; Sharma, R. A.; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
Some of the largest improvements in clinical outcomes for patients with solid cancers observed over the past 3 decades have been from concurrent treatment with chemotherapy and radiotherapy (RT). The lethal effects of RT on cancer cells arise primarily from damage to DNA. Ruthenium (Ru) is a transition metal of the platinum group, with potentially less toxicity than platinum drugs. We postulated that ruthenium-arene complexes are radiosensitisers when used in combination with RT. We screened 14 ruthenium-arene complexes and identified AH54 and AH63 as supra-additive radiosensitisers by clonogenic survival assays and isobologram analyses. Both complexes displayed facial chirality. At clinically relevant doses of RT, radiosensitisation of cancer cells by AH54 and AH63 was p53-dependent. Radiation enhancement ratios for 5–10 micromolar drug concentrations ranged from 1.19 to 1.82. In p53-wildtype cells, both drugs induced significant G2 cell cycle arrest and apoptosis. Colorectal cancer cells deficient in DNA damage repair proteins, EME1 and MUS81, were significantly more sensitive to both agents. Both drugs were active in cancer cell lines displaying acquired resistance to oxaliplatin or cisplatin. Our findings broaden the potential scope for these drugs for use in cancer therapy, including combination with radiotherapy to treat colorectal cancer
The potent anti-cancer activity of Dioclea lasiocarpa lectin
(Elsevier, 2017-07-16) Gondim, Ana C.S.; Romero Canelón, Isolda; Sousa, Eduardo H.S.; Blindauer, Claudia A.; Butler, Jennifer S.; Romero Castro, María José; Sánchez Cano, Carlos; Sousa, Bruno L.; Chaves, Renata P.; Nagano, Celso S.; Cavada, Benildo S.; Sadler, Peter J.; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
The lectin DLasiL was isolated from seeds of the Dioclea lasiocarpa collected from the northeast coast of Brazil and characterized for the first time by mass spectrometry, DNA sequencing, inductively coupled plasma-mass spectrometry, electron paramagnetic resonance, and fluorescence spectroscopy. The structure of DLasiL lectin obtained by homology modelling suggested strong conservation of the dinuclear Ca/Mn and sugar-binding sites, and dependence of the solvent accessibility of tryptophan-88 on the oligomerisation state of the protein. DLasiL showed highly potent (low nanomolar) antiproliferative activity against several human carcinoma cell lines including A2780 (ovarian), A549 (lung), MCF-7 (breast) and PC3 (prostate), and was as, or more, potent than the lectins ConBr (Canavalia brasiliensis), ConM (Canavalia maritima) and DSclerL (Dioclea sclerocarpa) against A2780 and PC3 cells. Interestingly, DLasiL lectin caused a G2/M arrest in A2780 cells after 24 h exposure, activating caspase 9 and delaying the on-set of apoptosis. Confocal microscopy showed that fluorescently-labelled DLasiL localized around the nuclei of A2780 cells at lectin doses of 0.5–2 × IC50 and gave rise to enlarged nuclei and spreading of the cells at high doses. These data reveal the interesting antiproliferative activity of DLasiL lectin, and suggest that further investigations to explore the potential of DLasiL as a new anticancer agent are warranted
An unusual assembled Pb(II) meso-helicate that shows the inert pair effect
(The Royal Society of Chemistry, 2016) Romero Castro, María José; Carballido, Rocío; Rodríguez Silva, Laura; Maneiro Maneiro, Marcelino; Zaragoza Vérez, Guillermo; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
A dinuclear Pb(II) mesocate has been prepared with an unprecedented four-coordinated kernel in which the Pb(II) lone pair is stereochemically active. This is the first time that this effect has been observed in a supramolecular Pb(II) helicate or meso-helicate.
Platinum(IV)-azido monocarboxylato complexes are photocytotoxic under irradiation with visible light
(The Royal Society of Chemistry, 2021-07-12) Shaili, Evyenia; Romero Castro, María José; Salassa, Luca; Woods, Julie A.; Butler, Jennifer S.; Romero-Canelón, Isolda; Clarkson, Guy; Habtemariam, Abraha; Sadler, Peter J.; Farrer, Nicola J.; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
Complexes trans,trans,trans-[Pt(N3)2(OH)(OCOR)(py)2] where py = pyridine and where OCOR = succinate (1); 4-oxo-4-propoxybutanoate (2) and N-methylisatoate (3) have been synthesized by derivation of trans,trans,trans-[Pt(OH)2(N3)2(py)2] (4) and characterised by NMR and EPR spectroscopy, ESI-MS and X-ray crystallography. Irradiation of 1–3 with green (517 nm) light initiated photoreduction to Pt(II) and release of the axial ligands at a 3-fold faster rate than for 4. TD-DFT calculations showed dissociative transitions at longer wavelengths for 1 compared to 4. Complexes 1 and 2 showed greater photocytotoxicity than 4 when irradiated with 420 nm light (A2780 cell line IC50 values: 2.7 and 3.7 μM) and complex 2 was particularly active towards the cisplatin-resistant cell line A2780cis (IC50 3.7 μM). Unlike 4, complexes 1–3 were phototoxic under green light irradiation (517 nm), with minimal toxicity in the dark. A pKa(H2O) of 5.13 for the free carboxylate group was determined for 1, corresponding to an overall negative charge during biological experiments, which crucially, did not appear to impede cellular accumulation and photocytotoxicity
Os2-Os4 switch controls DNA knotting and anticancer activity
(Wiley-VCH Verlag GmbH & Co. KGaA, 2016-05-30) Fu, Ying; Romero Castro, María José; Salassa, Luca; Cheng, Xi; Habtemariam, Abraha; Clarkson, Guy J.; Prokes, Ivan; Rodger, Alison; Costantini, Giovanni; Sadler, Peter J.; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to formametallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity
Cluster helicates: promising functional materials
(Royal Society of Chemistry, 2024-10-10) Fernández-Fariña, Sandra; Barreiro Sisto, Uxía; Martínez-Calvo, Miguel; Pedrido Castiñeiras, Rosa; González Noya, Ana María; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
Cluster helicates are a new type of supramolecular architecture that consists of a metal cluster wrapped around by ligands arranged in a helical mode. This class of compounds combines the unique properties of metal clusters with the sophisticated chiral arrangement found in helicates. Therefore, these architectures show promising applications in the development of advanced materials with specific electronic, magnetic, optical, catalytic and biological properties. This review delves into a few pioneering studies on cluster helicates and their applications as nanomagnetic, nanoelectric and catalyst materials. Furthermore, it emphasises the necessity for further exploration in this area and the fields related to the functional applications that cluster helicates can bring to the future of materials science.
A sequentially assembled grid composed of supramolecular meso-helical nodes
(The Royal Society of Chemistry, 2011) Martínez-Calvo, Miguel; Pedrido Castiñeiras, Rosa; González Noya, Ana María; Romero Castro, María José; Cwiklinska, Magdalena; Zaragoza Vérez, Guillermo; Bermejo Patiño, Manuel Rafael; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
A unique case of a grid-of-mesocates sequentially assembled by supramolecular cobalt(II) meso-helical units connected through hydrogen bonding is reported.
Unprecedent isolation of a mixture of conformational and linkage isomers in a thiosemicarbazone cobalt mesocate
(American Chemical Society, 2009) Zaragoza Vérez, Guillermo; Pedrido Castiñeiras, Rosa; Romero Castro, María José; González Noya, Ana María; Bermejo Patiño, Manuel Rafael; Martínez-Calvo, Miguel; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
A cobalt(II) thiosemicarbazonate mesocate has been structurally characterized as an unexpected mixture of conformational and linkage isomers. Moreover, we have shown that the absence of a nitrogen atom in the spacer of the helicand ligand H2La, enables the assembly of an achiral mesohelical complex in the case of Co(II) ions.
Metal self-recognition: a pathway to control the formation of dihelicates and mesocates
(The Royal Society of Chemistry, 2012) Zaragoza Vérez, Guillermo; Martínez-Calvo, Miguel; Romero Castro, María José; Pedrido Castiñeiras, Rosa; González Noya, Ana María; Bermejo Patiño, Manuel Rafael; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
We have studied the factors that affect the formation of different metallosupramolecular architectures by metal direct self-assembly. A synthetic route has been developed to obtain mesocates or dihelicates selectively. For this purpose a series of ﬁve bisthiosemicarbazone ligands derived from 1,3- diacetylbenzene were designed and synthesised. Namely H₂LMᵉ, H₂LEᵗ, H₂LPʰ, H₂LPʰN and H₂LPʰOMᵉ with different substituents on the 4-N terminal position of the thiosemicarbazone strands. The Co(II), Zn(II) and Cd(II) complexes of these ligands were prepared by an electrochemical procedure. Crystallographic studies revealed the formation of mesocates for Co(II) and Zn(II) metal ions whereas the Cd(II) complexes gave a bishelical supramolecular structure. Therefore these bisthiosemicarbazone ligands enable the selective isolation of mesocate or dihelicate complexes by using a speciﬁc metal ion.
A double-stranded dinuclear cadmium(II) helicate that assembles into chains in the solid state
(The Royal Society of Chemistry, 2010) Zaragoza Vérez, Guillermo; Martínez-Calvo, Miguel; González Noya, Ana María; Pedrido Castiñeiras, Rosa; Romero Castro, María José; Fernández García, María Isabel; Bermejo Patiño, Manuel Rafael; Universidade de Santiago de Compostela. Departamento de Química Inorgánica
A [4+4] double-stranded cadmium dihelicate was afforded from an easily accessible thiosemicarbazone ligand; its crystal structure reveals the assembly of two enantiomers into dihelicate pairs, these pairs being further connected into infinite linear chains.
A water reduction process performed by zinc metal under very mild conditions
(The Royal Society of Chemistry, 2010) Romero Castro, María José; Pedrido Castiñeiras, Rosa; González Noya, Ana María; Martínez-Calvo, Miguel; Zaragoza Vérez, Guillermo; Bermejo Patiño, Manuel Rafael; Universidade de Santiago de Compostela. Departamento de Química Inorgánica; Universidade de Santiago de Compostela. Departamento de Didácticas Aplicadas
Water reduction can be electrochemically promoted by zinc under very mild conditions, as demonstrated by the formation of the complex [Zn(H2O)6]Zn3(L)3(mu3-O)], whose anion consists of a Zn3O4 cluster incorporating a mu3-oxo anion.

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