Os2-Os4 switch controls DNA knotting and anticancer activity

Thumbnail Image

Files

2016_AngChem_Fu_OS2OS4.pdf (1.88 MB)
Identifiers
URI: https://hdl.handle.net/10347/44209
ISSN: 1433-7851
E-ISSN: 1521-3773
DOI: 10.1002/anie.201602995

Publication date

2016-05-30

Authors

Advisors

Tutors

Editors

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA
Metrics
Google Scholar
lacobus
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to formametallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity

Description

Keywords

Cancer| DNA| Organometallic| Osmium| Supramolecular

Bibliographic citation

Fu, Y., Romero, M. J., Salassa, L., Cheng, X., Habtemariam, A., Clarkson, G. J., Prokes, I., Rodger, A., Costantini, G., Sadler, P. J. (2016). "Os2-Os4 switch controls DNA knotting and anticancer activity", Angew. Chem. Int. Ed. , 55, 8909–8912

Relation

Has part

Has version

Is based on

Is part of

Is referenced by

Is version of

Requires

Sponsors

We thank the ERC (grant no. 247450 BIOINCMED), EPSRC (grant no. EP/F034210/1), BBSRC (grant no. BB/F011199/1), and Science City/EU ERDF/AWM for funding. G. C. acknowledges financial support through the ERC Grant “VISUAL-MS”. M.J.R. thanks Fundación Barrié fellowship. L.S. thanks the MC CIG fellowship UCnanomat4iPACT (grant no. 321791) and the MINECO grants (CTQ2012-39315 and RYC-2011-07787). We thank colleagues in the EC COST Action CM1105 for stimulating discussions, and Ben Moreton for his help with AFM

Rights

© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (CC BY 4.0; Attribution 4.0 International: https://creativecommons.org/licenses/by/4.0/). Open access article available at: https://doi.org/10.1002/anie.201602995
Attribution 4.0 International

Collections

Química Inorgánica
SUPRABIOIN