A heteronuclear ZnGd complex as a potential contrast agent for magnetic resonance imaging

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2016_ecsoc20_fondo_heteronuclear.pdf (550.78 KB)
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URI: http://hdl.handle.net/10347/25754
ISBN: 978-3-03842-192-4
DOI: 10.3390/ecsoc-20-b003

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2016

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Abstract

A new ligand H3L, with internal compartments for allocating 3d metal ions and external donors to bind 4f ions, was synthesized and completely characterized. Reaction of H3L with zinc(II) and gadolin ium(III) salts allows isolating the heteronuclear complex {[ZnGd(HL)(NO3)(OAc)(CH3OH)](NO3)}∙6H2O (1·6H2O). The ability of 1·6H2O to act as a magnetic resonance imaging (MRI) contrast agent was evaluated and this study shows that both the transversal and longitudinal relaxivities are quite high but the T1/T2 ratio of 7.9 indicates that it could have even greater potential as a T2 contrast agent

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The 20th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products

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Gadolinium| Zinc| MRI contrast agent| Schiff base| Imidazolidine

Bibliographic citation

Fondo, M., Corredoira-Vázquez, J., García-Deibe, A.M., Sanmartín-Matalobos, J., Iglesias, R. & Taboada, P. (2016). A heteronuclear ZnGd complex as a potential contrast agent for magnetic resonance imaging. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin. (Ed.), Proceedings ECSOC-20: The 20Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2016. MDPI. doi: 10.3390/ecsoc-20-b003

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© 2016 by MDPI, Basel, Switzerland. Open Access

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Química Inorgánica
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