High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

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2016_chemcommun_vazquez_high_sequence.pdf (2.07 MB)
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URI: http://hdl.handle.net/10347/17021
ISSN: 1359-7345
E-ISSN: 1364-548X
DOI: 10.1039/C5CC07619F

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2016

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Royal Society of Chemistry
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We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines

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Gamba, I., Salvadó, I., Brissos, R., Gamez, P., Brea, J., & Loza, M. et al. (2016). High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides. Chemical Communications, 52(6), 1234-1237. doi: 10.1039/c5cc07619f

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We are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, CTQ2014-55293-P and CTQ2013- 49317-EXP, the Xunta de Galicia GRC2013-041, the ERDF, and the European Research Council (Advanced Grant No. 340055). Support by the COST Action CM1105, and the ORFEO-CINQA network (CTQ2014-51912-REDC) is kindly acknowledged. I. S. thanks the Fundacio´n Jose´ Otero-Carmela Martı´nez for her PhD fellowship

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© The Royal Society of Chemistry 2016

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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Inorgánica
Química Orgánica