RT Journal Article
T1 High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides
A1 Gamba, Ilaria
A1 Salvadó, Iria
A1 Brissos, Rosa F.
A1 Gamez, Patrick
A1 Brea Floriani, José Manuel
A1 Loza García, María Isabel
A1 Vázquez Sentís, Marco Eugenio
A1 Vázquez López, Miguel
AB We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines
PB Royal Society of Chemistry
SN 1359-7345
YR 2016
FD 2016
LK http://hdl.handle.net/10347/17021
UL http://hdl.handle.net/10347/17021
LA eng
NO Gamba, I., Salvadó, I., Brissos, R., Gamez, P., Brea, J., & Loza, M. et al. (2016). High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides. Chemical Communications, 52(6), 1234-1237. doi: 10.1039/c5cc07619f
NO We are thankful for the support given by the Spanish grantsSAF2013-41943-R, CTQ2012-31341, CTQ2014-55293-P and CTQ2013-49317-EXP, the Xunta de Galicia GRC2013-041, the ERDF, and theEuropean Research Council (Advanced Grant No. 340055). Supportby the COST Action CM1105, and the ORFEO-CINQA network(CTQ2014-51912-REDC) is kindly acknowledged. I. S. thanks theFundacio´n Jose´ Otero-Carmela Martı´nez for her PhD fellowship
DS Minerva
RD 24 abr 2026