High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Inorgánicagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorGamba, Ilaria
dc.contributor.authorSalvadó, Iria
dc.contributor.authorBrissos, Rosa F.
dc.contributor.authorGamez, Patrick
dc.contributor.authorBrea Floriani, José Manuel
dc.contributor.authorLoza García, María Isabel
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorVázquez López, Miguel
dc.date.accessioned2018-07-13T12:27:49Z
dc.date.available2018-07-13T12:27:49Z
dc.date.issued2016
dc.description.abstractWe demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell linesgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, CTQ2014-55293-P and CTQ2013- 49317-EXP, the Xunta de Galicia GRC2013-041, the ERDF, and the European Research Council (Advanced Grant No. 340055). Support by the COST Action CM1105, and the ORFEO-CINQA network (CTQ2014-51912-REDC) is kindly acknowledged. I. S. thanks the Fundacio´n Jose´ Otero-Carmela Martı´nez for her PhD fellowshipgl
dc.identifier.citationGamba, I., Salvadó, I., Brissos, R., Gamez, P., Brea, J., & Loza, M. et al. (2016). High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides. Chemical Communications, 52(6), 1234-1237. doi: 10.1039/c5cc07619fgl
dc.identifier.doi10.1039/C5CC07619F
dc.identifier.essn1364-548X
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/10347/17021
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relation.publisherversionhttps://doi.org/10.1039/C5CC07619Fgl
dc.rights© The Royal Society of Chemistry 2016gl
dc.rights.accessRightsopen accessgl
dc.titleHigh-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptidesgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
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relation.isAuthorOfPublication49ee56a2-7094-407b-8108-b55c5968f241
relation.isAuthorOfPublication.latestForDiscovery67b19be7-64a8-45c8-a6e4-ed48a4410ef8

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