Interest of 3-arylcoumarins as xanthine oxidase inhibitors
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Abstract
In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout
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The 19th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry
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Matos, M.J., Borges, F., Santanta, L., Uriarte, E., Medda, R., Pintus, F., Caboni, M., Era, B. Fais, A. & Di Petrillo, A. (2015). Interest of 3-arylcoumarins as xanthine oxidase inhibitors. In J.A. Seijas, M.P. Vázquez Tato & S.K. Lin, Proceedings ECSOC-19: The 19Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2015. MDPI. doi: 10.3390/ecsoc-19-b002
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© 2016 by MDPI, Basel, Switzerland. Open Access