3D self-assembly of cyclic peptides into multilayered nanosheets
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Royal Society of Chemistry
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Abstract
The hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptide design that allows hierarchical self-assembly in all three spatial dimensions to produce nanosheets composed of ordered nanotube layers. The uniformity of the nanosheet aspect ratio and thickness is consistent with the high packing order of the monomers observed in this 3D assembly.
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Díaz, S., Sanchez-Fernandez, A., Granja, J. R., Insua, I., & Montenegro, J. (2026). 3D self-assembly of cyclic peptides into multilayered nanosheets. Chemical Science, 17(13), 6727-6733. https://doi.org/10.1039/d5sc09489e
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https://doi.org/10.1039/D5SC09489ESponsors
This research was partially funded by Agencia Estatal de Investigación (PDC2021-121192-I00, PID2023-152181OB-I0, RYC2021-031367-I, PID2022-142440NB-I00, and PID2023-147885OA-I00), Xunta de Galicia (ED431G 2023/03, ED431C 2024/03, ED431C 2025/15 IN855A 2021/06, ED431F 2023/24, ED431C 2024/09, and 2025-CP047), Fundación la Caixa (TROPIC and HR23-00221), and the European Research Council (StG-DYNAP-677786 and StG-REPLICATE-101163359). We acknowledge the European Synchrotron Radiation Facility (ESRF) for provision of synchrotron radiation facilities under proposal number MX-2662, and we would like to thank Dr Petra Pernot for assistance and support in using beamline BM29
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This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.