3D self-assembly of cyclic peptides into multilayered nanosheets

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Enxeñaría Química
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.contributor.authorDíaz Arias, Sandra Natalia
dc.contributor.authorSánchez Fernández, Adrián
dc.contributor.authorGranja Guillán, Juan Ramón
dc.contributor.authorInsua López, Ignacio
dc.contributor.authorMontenegro García, Javier
dc.date.accessioned2026-04-20T08:21:17Z
dc.date.available2026-04-20T08:21:17Z
dc.date.issued2026-02-26
dc.description.abstractThe hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptide design that allows hierarchical self-assembly in all three spatial dimensions to produce nanosheets composed of ordered nanotube layers. The uniformity of the nanosheet aspect ratio and thickness is consistent with the high packing order of the monomers observed in this 3D assembly.
dc.description.peerreviewedSI
dc.description.sponsorshipThis research was partially funded by Agencia Estatal de Investigación (PDC2021-121192-I00, PID2023-152181OB-I0, RYC2021-031367-I, PID2022-142440NB-I00, and PID2023-147885OA-I00), Xunta de Galicia (ED431G 2023/03, ED431C 2024/03, ED431C 2025/15 IN855A 2021/06, ED431F 2023/24, ED431C 2024/09, and 2025-CP047), Fundación la Caixa (TROPIC and HR23-00221), and the European Research Council (StG-DYNAP-677786 and StG-REPLICATE-101163359). We acknowledge the European Synchrotron Radiation Facility (ESRF) for provision of synchrotron radiation facilities under proposal number MX-2662, and we would like to thank Dr Petra Pernot for assistance and support in using beamline BM29
dc.identifier.citationDíaz, S., Sanchez-Fernandez, A., Granja, J. R., Insua, I., & Montenegro, J. (2026). 3D self-assembly of cyclic peptides into multilayered nanosheets. Chemical Science, 17(13), 6727-6733. https://doi.org/10.1039/d5sc09489e
dc.identifier.doi10.1039/D5SC09489E
dc.identifier.essn2041-6539
dc.identifier.issn2041-6520
dc.identifier.urihttps://hdl.handle.net/10347/46806
dc.issue.number13
dc.journal.titleChemical Science
dc.language.isoeng
dc.page.final6733
dc.page.initial6727
dc.publisherRoyal Society of Chemistry
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-152181OB-I0/ES/QUIMICA DINAMICA Y PROTOTIPOS SUPERCAOTROPICOS PARA TRANSPORTE DE MEMBRANA
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142440NB-I00/ES/ATERIALES SUPRAMOLECULARES BASADOS EN PEPTIDOS CICLICOS. UNA APROXIMACION SUPRAMOLECULAR QUIMIOTERAPEUTICA
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-147885OA-I00/ES/AUTO-ENSAMBLAJE DE NANOFIBRAS PEPTIDICAS ANTIMICROBIANAS EN EL CITOSOL DE BACTERIAS
dc.relation.publisherversionhttps://doi.org/10.1039/D5SC09489E
dc.rightsThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
dc.rights.accessRightsopen access
dc.subject.classification3303 ingeniería y tecnología químicas
dc.title3D self-assembly of cyclic peptides into multilayered nanosheets
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number17
dspace.entity.typePublication
relation.isAuthorOfPublication03da9e96-b84c-43f0-8125-c2cb5bcec338
relation.isAuthorOfPublication1535e177-ee84-4b2f-8ef9-48de2b07ad1e
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relation.isAuthorOfPublication.latestForDiscovery03da9e96-b84c-43f0-8125-c2cb5bcec338

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