RT Journal Article
T1 3D self-assembly of cyclic peptides into multilayered nanosheets
A1 Díaz Arias, Sandra Natalia
A1 Sánchez Fernández, Adrián
A1 Granja Guillán, Juan Ramón
A1 Insua López, Ignacio
A1 Montenegro García, Javier
AB The hierarchical self-assembly of three-dimensional (3D) supramolecular materials presents a significant challenge in molecular design. This process requires monomers with specific packing geometries and orthogonal contacts to enable multidimensional elongation. Here, we describe a new cyclic peptide design that allows hierarchical self-assembly in all three spatial dimensions to produce nanosheets composed of ordered nanotube layers. The uniformity of the nanosheet aspect ratio and thickness is consistent with the high packing order of the monomers observed in this 3D assembly.
PB Royal Society of Chemistry
SN 2041-6520
YR 2026
FD 2026-02-26
LK https://hdl.handle.net/10347/46806
UL https://hdl.handle.net/10347/46806
LA eng
NO Díaz, S., Sanchez-Fernandez, A., Granja, J. R., Insua, I., & Montenegro, J. (2026). 3D self-assembly of cyclic peptides into multilayered nanosheets. Chemical Science, 17(13), 6727-6733. https://doi.org/10.1039/d5sc09489e
NO This research was partially funded by Agencia Estatal de Investigación (PDC2021-121192-I00, PID2023-152181OB-I0, RYC2021-031367-I, PID2022-142440NB-I00, and PID2023-147885OA-I00), Xunta de Galicia (ED431G 2023/03, ED431C 2024/03, ED431C 2025/15 IN855A 2021/06, ED431F 2023/24, ED431C 2024/09, and 2025-CP047), Fundación la Caixa (TROPIC and HR23-00221), and the European Research Council (StG-DYNAP-677786 and StG-REPLICATE-101163359). We acknowledge the European Synchrotron Radiation Facility (ESRF) for provision of synchrotron radiation facilities under proposal number MX-2662, and we would like to thank Dr Petra Pernot for assistance and support in using beamline BM29
DS Minerva
RD 22 may 2026