Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions
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ISSN: 1083-6160
E-ISSN: 1520-586X
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American Chemical Society
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Abstract
Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadings
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in Org. Process Res. Dev., copyright © 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://doi.org/10.1021/acs.oprd.9b00191
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Org. Process Res. Dev. 2019, 23, 8, 1669-1673
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https://doi.org/10.1021/acs.oprd.9b00191Sponsors
This work received financial support from Spanish grants (SAF2016-76689-R, CTQ2016-77047-P, and Juan de la Cierva-Incorporación Fellowship IJCI-2017-31450 to M.F.), the Consellería de Cultura, Educación e Ordenación Universitaria (ED431C 2017/19, 2015-CP082, and Centro Singular de Investigación de Galicia Accreditation 2016–2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant 340055). The orfeo-cinqa network (CTQ2016-81797-REDC) is also kindly acknowledged
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© 2019 American Chemical Society