RT Journal Article
T1 Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions
A1 Gulías Costa, Moisés
A1 Marcos-Atanes, Daniel
A1 Mascareñas Cid, José Luis
A1 Font Molíns, Marc
K1 Multigram-scale synthesis
K1 Benzoxepines
K1 Coumarins
AB Herein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadings
PB American Chemical Society
SN 1083-6160
YR 2019
FD 2019
LK http://hdl.handle.net/10347/20793
UL http://hdl.handle.net/10347/20793
LA eng
NO Org. Process Res. Dev. 2019, 23, 8, 1669-1673
NO This document is the Accepted Manuscript version of a Published Work that appeared in final form in Org. Process Res. Dev., copyright © 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://doi.org/10.1021/acs.oprd.9b00191
NO This work received financial support from Spanish grants (SAF2016-76689-R, CTQ2016-77047-P, and Juan de la Cierva-Incorporación Fellowship IJCI-2017-31450 to M.F.), the Consellería de Cultura, Educación e Ordenación Universitaria (ED431C 2017/19, 2015-CP082, and Centro Singular de Investigación de Galicia Accreditation 2016–2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant 340055). The orfeo-cinqa network (CTQ2016-81797-REDC) is also kindly acknowledged
DS Minerva
RD 23 abr 2026