Practical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactions

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorGulías Costa, Moisés
dc.contributor.authorMarcos-Atanes, Daniel
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorFont Molíns, Marc
dc.date.accessioned2020-02-20T09:14:57Z
dc.date.available2020-07-15T01:00:10Z
dc.date.issued2019
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Org. Process Res. Dev., copyright © 2019 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://doi.org/10.1021/acs.oprd.9b00191gl
dc.description.abstractHerein we disclose the assembly of benzoxepines and coumarins from 2-alkenylphenol precursors using [Cp*RhCl2]2 as the precatalyst and alkynes or carbon monoxide as reacting partners. The preparation of benzoxepines and coumarins can be scaled up to 33 mmol using low catalyst loadingsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work received financial support from Spanish grants (SAF2016-76689-R, CTQ2016-77047-P, and Juan de la Cierva-Incorporación Fellowship IJCI-2017-31450 to M.F.), the Consellería de Cultura, Educación e Ordenación Universitaria (ED431C 2017/19, 2015-CP082, and Centro Singular de Investigación de Galicia Accreditation 2016–2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant 340055). The orfeo-cinqa network (CTQ2016-81797-REDC) is also kindly acknowledgedgl
dc.identifier.citationOrg. Process Res. Dev. 2019, 23, 8, 1669-1673gl
dc.identifier.doi10.1021/acs.oprd.9b00191
dc.identifier.essn1520-586X
dc.identifier.issn1083-6160
dc.identifier.urihttp://hdl.handle.net/10347/20793
dc.language.isoenggl
dc.publisherAmerican Chemical Societygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76689-R/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797-REDC/ES
dc.relation.publisherversionhttps://doi.org/10.1021/acs.oprd.9b00191gl
dc.rights© 2019 American Chemical Societygl
dc.rights.accessRightsopen accessgl
dc.subjectMultigram-scale synthesisgl
dc.subjectBenzoxepinesgl
dc.subjectCoumarinsgl
dc.titlePractical, Large-Scale Preparation of Benzoxepines and Coumarins through Rhodium(III)-Catalyzed C–H Activation/Annulation Reactionsgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
relation.isAuthorOfPublication47a6a088-27a9-412e-8422-0de4fd8af0d4
relation.isAuthorOfPublicationfbcc313d-9cf6-48e4-b938-6430092aa8ae
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery47a6a088-27a9-412e-8422-0de4fd8af0d4

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