Anion Recognition as a Supramolecular Switch of Cell Internalization
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American Chemical Society
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Abstract
The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own
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Rodríguez, J., Mosquera, J., Couceiro, J., Nitschke, J., Vázquez, M., & Mascareñas, J. (2016). Anion Recognition as a Supramolecular Switch of Cell Internalization. Journal Of The American Chemical Society, 139(1), 55-58. doi: 10.1021/jacs.6b11103
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https://doi.org/10.1021/jacs.6b11103Sponsors
We are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2015-70698-R, and CTQ2013-49317-EXP, the Consellerı́a de Cultura, Educación e Ordenación Universitaria (GRC2013-041 and Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant No. 340055). Support of the orfeo-cinqa network (CTQ2014-51912-REDC) is kindly acknowledged. J.R. thanks the Xunta de Galicia for her Ph.D. fellowship, and J.M. thanks Fundación Ramón Areces for his postdoctoral fellowship
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© 2017 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes