Anion Recognition as a Supramolecular Switch of Cell Internalization

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorRodríguez Couceiro, José
dc.contributor.authorNitschke, Jonathan R.
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-27T13:50:15Z
dc.date.available2019-03-27T13:50:15Z
dc.date.issued2016
dc.description.abstractThe cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their owngl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2015-70698-R, and CTQ2013-49317-EXP, the Consellerı́a de Cultura, Educación e Ordenación Universitaria (GRC2013-041 and Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant No. 340055). Support of the orfeo-cinqa network (CTQ2014-51912-REDC) is kindly acknowledged. J.R. thanks the Xunta de Galicia for her Ph.D. fellowship, and J.M. thanks Fundación Ramón Areces for his postdoctoral fellowshipgl
dc.identifier.citationRodríguez, J., Mosquera, J., Couceiro, J., Nitschke, J., Vázquez, M., & Mascareñas, J. (2016). Anion Recognition as a Supramolecular Switch of Cell Internalization. Journal Of The American Chemical Society, 139(1), 55-58. doi: 10.1021/jacs.6b11103gl
dc.identifier.doi10.1021/jacs.6b11103
dc.identifier.essn1520-5126
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/10347/18481
dc.language.isoenggl
dc.publisherAmerican Chemical Societygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-49317/ES/EXPLORACION DE TERAPIAS ANTITUMORALES ALTERNATIVAS DIRIGIDAS A LAS MITOCONDRIAS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-70698-R/ES/SISTEMAS SUPRAMOLECULARES PARA RECONOCIMIENTO BIOMOLECULAR: HELICATOS PEPTIDICOS Y RECEPTORES OLIGOMERICOS AUTOENSAMBLADOS
dc.relation.publisherversionhttps://doi.org/10.1021/jacs.6b11103gl
dc.rights© 2017 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposesgl
dc.rights.accessRightsopen accessgl
dc.titleAnion Recognition as a Supramolecular Switch of Cell Internalizationgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
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relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
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relation.isAuthorOfPublication.latestForDiscovery1b4c7a3c-215b-42bf-9ce2-c533031318dc

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