Stereoselective self-assembly of DNA binding helicates directed by the Viral β-Annulus Trimeric Peptide Motif
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Abstract
Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions
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Bioconjugate Chem. 2021, 32, 1564−1569. https://doi.org/10.1021/acs.bioconjchem.1c00312
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https://doi.org/10.1021/acs.bioconjchem.1c00312Sponsors
Financial support from the Spanish grant RTI2018-099877-B-I00, the Xunta de Galicia (Centro singular de Investigación de Galicia accreditation 2016–2019, ED431G/09, and ED431B 2018/04), and the European Union (European Regional Development Fund - ERDF) is gratefully acknowledged. J.G.-G. thanks the Spanish MINECO for his FPI fellowship. D.B. thanks the CIQUS for his 2018 PhD fellowship. G.S. and J.-D.M. thank Spanish MINECO (grant CTQ2017-87889-P) and Generalitat de Catalunya (2017SGR1323) for the financial support. Finally, we would like to thank Prof. Kazunori Matsuura at Tottori University for his valuable input during the preparation of this manuscript
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© 2021 American Chemical Society. This work is licenced under a Creative Commons Attribution 4.0 International licence (https://creativecommons.org/licenses/by/4.0/legalcode) Atribución 4.0 Internacional