RT Journal Article
T1 Stereoselective self-assembly of DNA binding helicates directed by the Viral β-Annulus Trimeric Peptide Motif
A1 Gómez González, Jacobo
A1 Bouzada Reboredo, David
A1 Pérez Márquez, Lidia Ana
A1 Sciortino, Giuseppe
A1 Maréchal, Jean-Didier
A1 Vázquez López, Miguel
A1 Vázquez  Sentis, Marco Eugenio
K1 Genetics
K1 Ligands
K1 Monomers
K1 Peptides and proteins
K1 Supramolecular structures and assemblies
AB Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions
PB ACS Publications
SN 1043-1802
YR 2021
FD 2021
LK http://hdl.handle.net/10347/29039
UL http://hdl.handle.net/10347/29039
LA eng
NO Bioconjugate Chem. 2021, 32, 1564−1569. https://doi.org/10.1021/acs.bioconjchem.1c00312
NO Financial support from the Spanish grant RTI2018-099877-B-I00, the Xunta de Galicia (Centro singular de Investigación de Galicia accreditation 2016–2019, ED431G/09, and ED431B 2018/04), and the European Union (European Regional Development Fund - ERDF) is gratefully acknowledged. J.G.-G. thanks the Spanish MINECO for his FPI fellowship. D.B. thanks the CIQUS for his 2018 PhD fellowship. G.S. and J.-D.M. thank Spanish MINECO (grant CTQ2017-87889-P) and Generalitat de Catalunya (2017SGR1323) for the financial support. Finally, we would like to thank Prof. Kazunori Matsuura at Tottori University for his valuable input during the preparation of this manuscript
DS Minerva
RD 29 abr 2026