Stereoselective self-assembly of DNA binding helicates directed by the Viral β-Annulus Trimeric Peptide Motif

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Inorgánicagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorGómez González, Jacobo
dc.contributor.authorBouzada Reboredo, David
dc.contributor.authorPérez Márquez, Lidia Ana
dc.contributor.authorSciortino, Giuseppe
dc.contributor.authorMaréchal, Jean-Didier
dc.contributor.authorVázquez López, Miguel
dc.contributor.authorVázquez Sentis, Marco Eugenio
dc.date.accessioned2022-08-09T08:18:28Z
dc.date.available2022-08-09T08:18:28Z
dc.date.issued2021
dc.description.abstractCombining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctionsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipFinancial support from the Spanish grant RTI2018-099877-B-I00, the Xunta de Galicia (Centro singular de Investigación de Galicia accreditation 2016–2019, ED431G/09, and ED431B 2018/04), and the European Union (European Regional Development Fund - ERDF) is gratefully acknowledged. J.G.-G. thanks the Spanish MINECO for his FPI fellowship. D.B. thanks the CIQUS for his 2018 PhD fellowship. G.S. and J.-D.M. thank Spanish MINECO (grant CTQ2017-87889-P) and Generalitat de Catalunya (2017SGR1323) for the financial support. Finally, we would like to thank Prof. Kazunori Matsuura at Tottori University for his valuable input during the preparation of this manuscriptgl
dc.identifier.citationBioconjugate Chem. 2021, 32, 1564−1569. https://doi.org/10.1021/acs.bioconjchem.1c00312gl
dc.identifier.doi10.1021/acs.bioconjchem.1c00312
dc.identifier.issn1043-1802
dc.identifier.urihttp://hdl.handle.net/10347/29039
dc.language.isoenggl
dc.publisherACS Publicationsgl
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099877-B-I00/ES/PLATAFORMAS PEPTIDICAS PARA APLICACIONES EN QUIMICA (BIO)SUPRAMOLECULAR Y DE MATERIALES, CATALISIS Y SENSORES (SWISSKNIFE)gl
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-87889-P/ES/DE LA CATALISIS MOLECULAR A LA SUPRA-BIO-CATALISIS, UN ENFOQUE COMPUTACIONALgl
dc.relation.publisherversionhttps://doi.org/10.1021/acs.bioconjchem.1c00312gl
dc.rights© 2021 American Chemical Society. This work is licenced under a Creative Commons Attribution 4.0 International licence (https://creativecommons.org/licenses/by/4.0/legalcode) Atribución 4.0 Internacionalgl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGeneticsgl
dc.subjectLigandsgl
dc.subjectMonomersgl
dc.subjectPeptides and proteinsgl
dc.subjectSupramolecular structures and assembliesgl
dc.titleStereoselective self-assembly of DNA binding helicates directed by the Viral β-Annulus Trimeric Peptide Motifgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication811a1eac-4048-4ed9-a56f-c1104cc20827
relation.isAuthorOfPublication49ee56a2-7094-407b-8108-b55c5968f241
relation.isAuthorOfPublication.latestForDiscovery811a1eac-4048-4ed9-a56f-c1104cc20827

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