The Reactions of Mitomycin C with Dithiols I. Reductive Activation

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2010_ecsoc14_paz_reactionsI.pdf (179.76 KB)
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URI: http://hdl.handle.net/10347/26882
ISBN: 3-906980-24-3
DOI: 10.3390/ecsoc-14-00482

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2010

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MDPI
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We report that the clinically used antitumor drug mitomycin C is reductively activated in vitro by simple thiols; a mechanism for this activation is proposed based on kinetic data and the identification of mitosene metabolites. The biological implications of these findings are discussed

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The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry

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Proceedings of the 14th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2010, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-14-00482

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© 2010 The author(s). Published by MDPI, Basel, Switzerland. Open Access

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Química Orgánica