Ruthenium-Catalyzed Redox Isomerizations inside Living Cells

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URI: http://hdl.handle.net/10347/18732
ISSN: 0002-7863
E-ISSN: 1520-5126
DOI: 10.1021/jacs.9b00837

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2019

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American Chemical Society
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Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the “in cellulo” generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells

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Vidal, C., Tomás-Gamasa, M., Gutiérrez-González, A., & Mascareñas, J. (2019). Ruthenium-Catalyzed Redox Isomerizations inside Living Cells. J. Am. Chem. Soc., 2019, 141 (13), pp 5125–5129. doi: 10.1021/jacs.9b00837

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This work has received financial support from the Spanish Government (SAF2016-76689-R, Orfeo-cinqa network CTQ2016-81797-REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015-CP082, ED431C 2017/19), Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund-ERDF), and the European Research Council (Advanced Grant No. 340055)

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© 2019 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes
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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica