Ruthenium-Catalyzed Redox Isomerizations inside Living Cells
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares | gl |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Química Orgánica | gl |
| dc.contributor.author | Vidal Vides, Cristian | |
| dc.contributor.author | Tomás Gamasa, María | |
| dc.contributor.author | Gutiérrez González, Alejandro | |
| dc.contributor.author | Mascareñas Cid, José Luis | |
| dc.date.accessioned | 2019-05-02T11:48:51Z | |
| dc.date.available | 2019-05-02T11:48:51Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the “in cellulo” generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells | gl |
| dc.description.peerreviewed | SI | gl |
| dc.description.sponsorship | This work has received financial support from the Spanish Government (SAF2016-76689-R, Orfeo-cinqa network CTQ2016-81797-REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015-CP082, ED431C 2017/19), Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund-ERDF), and the European Research Council (Advanced Grant No. 340055) | gl |
| dc.identifier.citation | Vidal, C., Tomás-Gamasa, M., Gutiérrez-González, A., & Mascareñas, J. (2019). Ruthenium-Catalyzed Redox Isomerizations inside Living Cells. J. Am. Chem. Soc., 2019, 141 (13), pp 5125–5129. doi: 10.1021/jacs.9b00837 | gl |
| dc.identifier.doi | 10.1021/jacs.9b00837 | |
| dc.identifier.essn | 1520-5126 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.uri | http://hdl.handle.net/10347/18732 | |
| dc.language.iso | eng | gl |
| dc.publisher | American Chemical Society | gl |
| dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/340055 | |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797/ES | |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76689-R/ES | |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797-REDC/ES | |
| dc.relation.publisherversion | https://doi.org/10.1021/jacs.9b00837 | gl |
| dc.rights | © 2019 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes | gl |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
| dc.rights.accessRights | open access | gl |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.title | Ruthenium-Catalyzed Redox Isomerizations inside Living Cells | gl |
| dc.type | journal article | gl |
| dc.type.hasVersion | VoR | gl |
| dspace.entity.type | Publication | |
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