RT Journal Article
T1 Ruthenium-Catalyzed Redox Isomerizations inside Living Cells
A1 Vidal Vides, Cristian
A1 Tomás Gamasa, María
A1 Gutiérrez González, Alejandro
A1 Mascareñas Cid, José Luis
AB Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the “in cellulo” generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells
PB American Chemical Society
SN 0002-7863
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18732
UL http://hdl.handle.net/10347/18732
LA eng
NO Vidal, C., Tomás-Gamasa, M., Gutiérrez-González, A., & Mascareñas, J. (2019). Ruthenium-Catalyzed Redox Isomerizations inside Living Cells. J. Am. Chem. Soc., 2019, 141 (13), pp 5125–5129. doi: 10.1021/jacs.9b00837
NO This work has received financial support from the Spanish Government (SAF2016-76689-R, Orfeo-cinqa network CTQ2016-81797-REDC), the Consellería de Cultura, Educación e Ordenación Universitaria (2015-CP082, ED431C 2017/19), Centro Singular de Investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund-ERDF), and the European Research Council (Advanced Grant No. 340055)
DS Minerva
RD 4 may 2026