YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells
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Cell Press
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Abstract
Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells. The PcG-independent functions of YY1 are also
reported, although their underlying mechanism is still undefined. This paper reports the role of YY1 and BAF complex in the OCT4-mediated pluripotency network in mouse embryonic stem cells (mESCs). The interaction between YY1 and BAF complex promotes mESC proliferation and pluripotency. Knockdown of Yy1 or Smarca4, the core component of the BAF complex, downregulates pluripotency
markers and upregulates several differentiation markers. Moreover, YY1 enriches at both promoter and super-enhancer regions to stimulate transcription. Thus, this study elucidates the role of YY1 in regulating pluripotency through its interaction with OCT4 and the BAF
complex and the role of BAF complex in integrating YY1 into the core pluripotency network
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Wang,J., Wu, X., Wei, C., Huang, X., Ma, Q., Huang, X. et al. (2018). YY1 positively regulates transcription by targeting promoters and super-enhancers through the BAF complex in embryonic stem cells. Stem Cell Reports, vol. 10, 1324-1339
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https://doi.org/10.1016/j.stemcr.2018.02.004Sponsors
This research was funded by grants from the National Key
Research and Development Program (2016YFA [0101700] and
2017YFA0102800), the National Natural Science Foundation of
China (31771639), the Guangdong Innovative and Entrepreneurial Research Team Program 2016ZT06S029, the Fundamental
Research Funds for the Central Universities (17ykzd04), and Thousand Youth Talents Plan to J.D., the National Natural Science Foundation of China (81703086) to J.W. and the NIH (1R01-GM095942
and 1R21HD087722) and the Empire State Stem Cell funded
through the New York State Department of Health (NYSTEM;
C028103 and C028121) to J.W.
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© 2018 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)