RT Journal Article
T1 YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells
A1 Wang, Jia
A1 Wu, Xingui
A1 Wei, Chao
A1 Huang, Xin
A1 Ma, Qian
A1 Huang, Xiaona
A1 Fabiola, Francesco
A1 Guallar Artal, Diana
A1 Fidalgo Pérez, Miguel Ángel
A1 Huang, Tingyuan
A1 Peng, Di
A1 Chen, Li
A1 Yu, Haopeng
A1 Li, Xingyu
A1 Sun, Junyi
A1 Liu, Xinyi
K1 Polycomb group
K1 Protein-dependent
K1 Knockdown of Yy1 or Smarca4
K1 YY1
K1 PcG-independent
AB Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells. The PcG-independent functions of YY1 are alsoreported, although their underlying mechanism is still undefined. This paper reports the role of YY1 and BAF complex in the OCT4-mediated pluripotency network in mouse embryonic stem cells (mESCs). The interaction between YY1 and BAF complex promotes mESC proliferation and pluripotency. Knockdown of Yy1 or Smarca4, the core component of the BAF complex, downregulates pluripotencymarkers and upregulates several differentiation markers. Moreover, YY1 enriches at both promoter and super-enhancer regions to stimulate transcription. Thus, this study elucidates the role of YY1 in regulating pluripotency through its interaction with OCT4 and the BAFcomplex and the role of BAF complex in integrating YY1 into the core pluripotency network
PB Cell Press
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22631
UL http://hdl.handle.net/10347/22631
LA eng
NO Wang,J., Wu, X., Wei, C., Huang, X., Ma, Q., Huang, X. et al. (2018). YY1 positively regulates transcription by targeting promoters and super-enhancers through the BAF complex in embryonic stem cells. Stem Cell Reports, vol. 10, 1324-1339
NO This research was funded by grants from the National KeyResearch and Development Program (2016YFA [0101700] and2017YFA0102800), the National Natural Science Foundation ofChina (31771639), the Guangdong Innovative and Entrepreneurial Research Team Program 2016ZT06S029, the FundamentalResearch Funds for the Central Universities (17ykzd04), and Thousand Youth Talents Plan to J.D., the National Natural Science Foundation of China (81703086) to J.W. and the NIH (1R01-GM095942and 1R21HD087722) and the Empire State Stem Cell fundedthrough the New York State Department of Health (NYSTEM;C028103 and C028121) to J.W.
DS Minerva
RD 24 abr 2026