RT Journal Article
T1 Os2-Os4 switch controls DNA knotting and anticancer activity
A1 Fu, Ying
A1 Romero Castro, María José
A1 Salassa, Luca
A1 Cheng, Xi
A1 Habtemariam, Abraha
A1 Clarkson, Guy J.
A1 Prokes, Ivan
A1 Rodger, Alison
A1 Costantini, Giovanni
A1 Sadler, Peter J.
K1 Cancer
K1 DNA
K1 Organometallic
K1 Osmium
K1 Supramolecular
AB Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to formametallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity
PB Wiley-VCH Verlag GmbH & Co. KGaA
SN 1433-7851
YR 2016
FD 2016-05-30
LK https://hdl.handle.net/10347/44209
UL https://hdl.handle.net/10347/44209
LA eng
NO Fu, Y., Romero, M. J., Salassa, L., Cheng, X., Habtemariam, A., Clarkson, G. J., Prokes,  I., Rodger, A., Costantini, G., Sadler, P. J. (2016). "Os2-Os4 switch controls DNA knotting and anticancer activity", Angew. Chem. Int. Ed. , 55, 8909–8912
NO We thank the ERC (grant no. 247450 BIOINCMED), EPSRC (grant no. EP/F034210/1), BBSRC (grant no. BB/F011199/1), and Science City/EU ERDF/AWM for funding. G. C. acknowledges financial support through the ERC Grant “VISUAL-MS”. M.J.R. thanks Fundación Barrié fellowship. L.S. thanks the MC CIG fellowship UCnanomat4iPACT (grant no. 321791) and the MINECO grants (CTQ2012-39315 and RYC-2011-07787). We thank colleagues in the EC COST Action CM1105 for stimulating discussions, and Ben Moreton for his help with AFM
DS Minerva
RD 23 may 2026