MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
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Abstract
We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria
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Sánchez, M., Martínez-Costas, J., Mascareñas, J., & Vázquez, M. (2014). MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria. ACS Chemical Biology, 9(12), 2742-2747. doi: 10.1021/cb500552f
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https://doi.org/10.1021/cb500552fSponsors
We are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, and BFU2013-43513-R, the Xunta de Galicia, GRC2013-041, the ERDF and the European Research Council (Advanced Grant Na 340055). M.I.S. thanks the Spanish MCINN for his Ph.D. fellowship. We also thank the insights and advice kindly provided by Prof. M. Murphy (MRC Mitochondrial Biology Unit)
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© 2014 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes