MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Moleculargl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorSánchez López, Mateo Isidro
dc.contributor.authorMartínez Costas, José Manuel
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.date.accessioned2019-03-27T11:54:02Z
dc.date.available2019-03-27T11:54:02Z
dc.date.issued2014
dc.description.abstractWe report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondriagl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, and BFU2013-43513-R, the Xunta de Galicia, GRC2013-041, the ERDF and the European Research Council (Advanced Grant Na 340055). M.I.S. thanks the Spanish MCINN for his Ph.D. fellowship. We also thank the insights and advice kindly provided by Prof. M. Murphy (MRC Mitochondrial Biology Unit)gl
dc.identifier.citationSánchez, M., Martínez-Costas, J., Mascareñas, J., & Vázquez, M. (2014). MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria. ACS Chemical Biology, 9(12), 2742-2747. doi: 10.1021/cb500552fgl
dc.identifier.doi10.1021/cb500552f
dc.identifier.essn1554-8937
dc.identifier.issn1554-8929
dc.identifier.urihttp://hdl.handle.net/10347/18473
dc.language.isoenggl
dc.publisherAmerican Chemical Societygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-43513-R/ES/REOVIRUS AVIAR: FACTORES DE VIRULENCIA Y NUEVAS DIANAS TERAPEUTICAS
dc.relation.publisherversionhttps://doi.org/10.1021/cb500552fgl
dc.rights© 2014 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposesgl
dc.rights.accessRightsopen accessgl
dc.titleMitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondriagl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
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relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication.latestForDiscoveryf55dab55-97e6-4c7d-9b63-71097cbf7aa4

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