RT Journal Article
T1 MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria
A1 Sánchez López, Mateo Isidro
A1 Martínez Costas, José Manuel
A1 Mascareñas Cid, José Luis
A1 Vázquez Sentís, Marco Eugenio
AB We report the discovery of a fluorogenic dye, N1,N3-di(2-aminidonaphthalen-6-yl) propane-1,3-diamine, MitoBlue, which selectively stains functional mitochondria while displaying low toxicity, bright blue emission, and high resistance to photobleaching. Additionally, we show that a biotin-labeled MitoBlue derivative can be used as a handle for the delivery of streptavidin-tagged species to the mitochondria
PB American Chemical Society
SN 1554-8929
YR 2014
FD 2014
LK http://hdl.handle.net/10347/18473
UL http://hdl.handle.net/10347/18473
LA eng
NO Sánchez, M., Martínez-Costas, J., Mascareñas, J., & Vázquez, M. (2014). MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria. ACS Chemical Biology, 9(12), 2742-2747. doi: 10.1021/cb500552f
NO We are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, and BFU2013-43513-R, the Xunta de Galicia, GRC2013-041, the ERDF and the European Research Council (Advanced Grant Na 340055). M.I.S. thanks the Spanish MCINN for his Ph.D. fellowship. We also thank the insights and advice kindly provided by Prof. M. Murphy (MRC Mitochondrial Biology Unit)
DS Minerva
RD 24 abr 2026