Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light

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URI: http://hdl.handle.net/10347/11968
ISSN: 1364-548X
DOI: 10.1039/c4cc04512b

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2014-07-28

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Royal Society of Chemistry
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We report a photolabile biselectrophilic Ru(II) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As proof-of-concept, we describe the preparation of homo- and heterodimeric bZIP peptides whose DNA-binding properties can be turned off using visible light

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Mosquera, J., Sánchez, M. I., Vázquez, M. E. and Mascareñas, J. L. (2014), Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light. Chem. Commun., 50, 10975-10978 [doi: 10.1039/C4CC04512B]

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Spanish MINECO. Grant Numbers: SAF2010-20822-C02-01/02, CTQ2010-20714-C02-01/BQU, CSD2007-00006 ERDF Xunta de Galicia. Grant Numbers: GRC2010/12, GR2013-041, INCITE09 209084PR, EM2013/036 European Research Council. Grant Number: 340055 CAM. Grant Number: S2009/PPQ-1634, AVANCAT

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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica