Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain
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Abstract
The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. In vivo, OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. Overall, our findings suggest that OBEX has a protective effect against an obesogenic environment
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Carreira, M.C., Andrade, S., Gonzalez-Izquierdo, A. et al. Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain. Sci Rep 8, 17155 (2018). https://doi.org/10.1038/s41598-018-34840-7
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https://doi.org/10.1038/s41598-018-34840-7Sponsors
This work has been partially supported by Catalysis S.L., CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) (Grant CB06/0003 to F.F.C.), an initiative of the Instituto de Salud Carlos III of Spain which is supported by the regional development funding program (FEDER), Xunta de Galicia (Grant GRC2014/034 to F.F.C.), Instituto de SaludCaros III (Grant PI17/01287 to F.F.C.). AGIand M.C.C. are researchers under CIBERobn contracts. A.B.C. is a researcher funded by Fundación Ramón Domínguez
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© The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/