RT Journal Article
T1 Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain
A1 Couselo Carreira, Marcos
A1 Andrade, Sara María Monteiro Sousa
A1 González Izquierdo, Andrea
A1 Amil Diz, María
A1 Folgueira Cobos, Cintia
A1 Crujeiras Martínez, Ana Belén
A1 Casanueva Freijo, Felipe
K1 Endocrine system and metabolic diseases
K1 Endocrinology
K1 Obesity
AB The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with antiobesity activity. The effects of OBEX have been tested in vivo and in vitro. In vivo, OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. In vitro analysis with 3T3-F442A cells revealed anti-proliferative and anti-differentiation effects of OBEX. In addition, OBEX induced a clear reduction of the lipid load in mature adipocytes obtained from 3T3-F442A cells. Overall, our findings suggest that OBEX has a protective effect against an obesogenic environment
PB Nature Publishing Group
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22091
UL http://hdl.handle.net/10347/22091
LA eng
NO Carreira, M.C., Andrade, S., Gonzalez-Izquierdo, A. et al. Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain. Sci Rep 8, 17155 (2018). https://doi.org/10.1038/s41598-018-34840-7
NO This work has been partially supported by Catalysis S.L., CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) (Grant CB06/0003 to F.F.C.), an initiative of the Instituto de Salud Carlos III of Spain which is supported by the regional development funding program (FEDER), Xunta de Galicia (Grant GRC2014/034 to F.F.C.), Instituto de SaludCaros III (Grant PI17/01287 to F.F.C.). AGIand M.C.C. are researchers under CIBERobn contracts. A.B.C. is a researcher funded by Fundación Ramón Domínguez
DS Minerva
RD 23 abr 2026