Does the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysis

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psicoloxía Evolutiva e da Educaciónes_ES
dc.contributor.authorMallo López, Sabela Carme
dc.contributor.authorPatten, Scott
dc.contributor.authorIsmail, Zahinoor
dc.contributor.authorPereiro Rozas, Arturo X.
dc.contributor.authorFacal Mayo, David
dc.contributor.authorOtero Ortega, Carlos
dc.contributor.authorJuncos Rabadán, Onésimo
dc.date.accessioned2024-02-02T11:52:48Z
dc.date.available2024-02-02T11:52:48Z
dc.date.issued2020
dc.description.abstractBackground Neuropsychiatric Symptoms (NPS) are common in Mild Cognitive Impairment (MCI). The Neuropsychiatric Inventory (NPI) and its shorter version, the Neuropsychiatric Inventory Questionnaire (NPI-Q), are the most common measures to assess NPS. Our objective was to determine if NPI/NPI-Q ratings predict conversion from MCI to dementia. Methods Empirical longitudinal studies published in English or Spanish, concerned with the role of NPS as a risk factor for conversion from MCI to dementia, with a diagnosis of MCI following clinical criteria, that reported NPI/NPI-Q total score in converters versus non-converters, were included. Random effects models were used, and heterogeneity was explored with stratification and a random-effects meta-regression. The overall conversion rate and the standardized mean difference (SMD) for evolution, as a function of NPI/NPI-Q scores, were calculated. Results The overall conversion rate was 35 %. Mean NPI/NPI-Q ratings were higher in converters versus in non-converters, with the overall SMD approaching significance. Heterogeneity was observed in studies of more than two years of follow-up and in a study with a mean age of more than 80 years. This heterogeneity concerned the size, not the direction of the difference. Conclusions Our results suggest that NPI/NPI-Q ratings are associated with conversion from MCI to dementiaes_ES
dc.description.peerreviewedSIes_ES
dc.description.sponsorshipThis work was financially supported through FEDER founds by the Spanish Directorate General of Scientific and Technical Research (Project Ref. PSI2014-55316-C3-1-R), the National Research Agency (Spanish 'Ministry of Science, Innovation and Universities) (Project Ref. PSI2017-89389-C2-1-R) and by the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema Universitario de Galicia; GI-1807-USC: Ref. ED431-2017/27).es_ES
dc.identifier.citationReferences Mallo, S. C., Patten, S. B., Ismail, Z., Pereiro, A. X., Facal, D., Otero, C., & Juncos-Rabadán, O. (2020). Does the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysis. Ageing Research Reviews, 58, 101004es_ES
dc.identifier.doi10.1016/j.arr.2019.101004
dc.identifier.essn1872-9649
dc.identifier.issn1568-1637
dc.identifier.urihttp://hdl.handle.net/10347/32252
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PSI2014-55316-C3-1-R/ES/DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA: ESTUDIO LONGITUDINAL CON MARCADORES COGNITIVOS, PSICOFISIOLOGICOS, BIOLOGICOS Y DE NEUROIMAGEN/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PSI2017-89389-C2-1-R/ES/ESTUDIO LONGITUDINAL DEL DETERIORO COGNITIVO EN EL ENVEJECIMIENTO NORMAL, DCL Y EA. EFECTOS DE UN PROGRAMA INTEGRADO DE ESTIMULACION COGNITIVA POR VIDEO-JUEGOS Y ESTIMULACION/es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.arr.2019.101004es_ES
dc.rightsCC-BY-NC-NDes_ES
dc.rights.accessRightsopen accesses_ES
dc.subjectNeuropsychiatric symptomses_ES
dc.subjectMild cognitive impairmentes_ES
dc.subjectDementiaes_ES
dc.subjectNeuropsychiatric inventoryes_ES
dc.subjectNeuropsychiatric inventory questionnairees_ES
dc.subjectMeta-analysises_ES
dc.titleDoes the neuropsychiatric inventory predict progression from mild cognitive impairment to dementia? A systematic review and meta-analysises_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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