The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorVázquez Vázquez, Olalla
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-27T15:47:31Z
dc.date.available2019-03-27T15:47:31Z
dc.date.issued2014
dc.description.abstractWe report the selective modification of cysteine residues engineered in peptides that have two additional cysteine residues as part of a Cys2His2 zinc finger motif. The chemoselective modification is achieved, thanks to the protecting effect exerted by the zinc cation upon coordination with the native cysteines and histidines of the zinc-finger fold. The strategy allows a straightforward synthesis of DNA binding zinc finger constructsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe acknowledge the support from the Spanish grants SAF2010-20822-C02, CTQ2009-14431/BQU, CSD2007-00006, the Xunta de Galicia GRC2010/12, GRC2013-041 and INCITE09 209 084PR. J. R. thanks the Fundación Gil Dávila and the Xunta de Galicia and J. M. the Spanish MCINN for their PhD fellowshipsgl
dc.identifier.citationRodríguez, J., Mosquera, J., Vázquez, O., Vázquez, M., & Mascareñas, J. (2014). The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative. Chem. Commun.,50, 2258-2260. doi: 10.1039/c3cc47599agl
dc.identifier.doi10.1039/C3CC47599A
dc.identifier.essn1364-548X
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/10347/18487
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/SAF2010-20822-C02/ES/DISEÑO Y DESARROLLO DE PROCESOS ENANTIOSELECTIVOS CATALIZADOS POR METALES DE TRANSICION PARA LA OBTENCION DE ESTRUCTURAS POLICICLICAS BIOLOGICAMENTE RELAVANTES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC/Plan Nacional de I+D+i 2004-2007/CSD2007-00006/ES/Desarrollo de entidades organometálicas para reacciones de funcionalización selectiva en moléculas orgánicas
dc.relation.publisherversionhttps://doi.org/10.1039/C3CC47599Agl
dc.rights© The Royal Society of Chemistry 2014gl
dc.rights.accessRightsopen accessgl
dc.titleThe ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivativegl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
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relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery1b4c7a3c-215b-42bf-9ce2-c533031318dc

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