Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes
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Abstract
Rh(III) catalysts can promote a formal (4 + 2) intramolecular oxidative annulation between acrylic or benzoic acid derivatives and alkynes. The reaction, which involves a C–H activation process, allows for a rapid assembly of appealing bicyclic pyran-2-ones and tricyclic isocoumarin derivatives in moderate to good yields. The α-pyrone moiety of the products provides for further manipulations to obtain relatively complex cyclic skeletons in a very simple manner
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F. Fernández, D., Casanova, N., Mascareñas, J., & Gulías, M. (2019). Rhodium(III)-Catalyzed Intramolecular Annulations of Acrylic and Benzoic Acids to Alkynes. ACS Omega, 4(4), 6257-6263. doi: 10.1021/acsomega.9b00022
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https://doi.org/10.1021/acsomega.9b00022Sponsors
This work has received financial support from Spanish grants (SAF2016-76689-R, CTQ2016-77047-P, and FPI fellowship to D.F.F.), the Consellería de Cultura, Educación e Ordenación Universitaria (ED431C 2017/19, 2015-CP082, and Centro Singular de Investigación de Galicia acreditación 2016-2019, ED431G/09), the European Regional Development Fund (ERDF), and the European Research Council (Advanced Grant no. 340055). The orfeo-cinqa network CTQ2016-81797-REDC is also kindly acknowledged
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ACS AuthorChoice - This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional