New supramolecular concepts for the development of functional systems in cells and protocells

Abstract

In this manuscript, we have approached the development of new functional supramolecular systems from a chemical perspective and with the objective to modify or replicate cellular functions. The main driving force and link between the systems developed during this PhD work is the dynamic character of stimuli-responsiveness, which is crucial for their specific functional behaviour. The novel functional systems development focused on a protofilament cytoskeleton-mimetic system, a new ratiometric fluorescent SNARF probe with pH range sensitivity optimized and a pH sensitive antitumoral analogue of a natural venom.