Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculareses_ES
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicaes_ES
dc.contributor.authorD’Avino, Cinzia
dc.contributor.authorGutiérrez Hernández, Sara
dc.contributor.authorFeldhaus, Max
dc.contributor.authorTomás Gamasa, María
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2024-02-19T09:33:47Z
dc.date.available2024-02-19T09:33:47Z
dc.date.issued2024-01-26
dc.description.abstractPerforming abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.es_ES
dc.description.peerreviewedSIes_ES
dc.description.sponsorshipWe are thankful for the financial support of Spanish grants: RYC2020-029150-I and “ESF Investing in your future”, RTI2018-093813-J-I00, PID2019-108624RB-I00, and PID2022-137318OB-I00, funded by MCIN/AEI and by “ERDF A way of making Europe”. We also thank MCIN/ISCIII and the “European Union Next Generation EU/PRTR” (Grant IHRC22-00009), the ORFEO–CINQA network (RED2022-134287-T), the Consellería de Cultura, Educación e Ordenación Universitaria (Grant ED431C 2021/25 and Grant ED431G 2019/03: Centro Singular de Investigación de Galicia accreditation 2019-2022), and the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014-2020). Figures have been created with https://BioRender.com.es_ES
dc.identifier.citationJ. Am. Chem. Soc. 2024, 146, 5, 2895–2900es_ES
dc.identifier.doi10.1021/jacs.3c13647
dc.identifier.urihttp://hdl.handle.net/10347/32853
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093813-J-I00/ES/FOTOCATALISIS BIOORTOGONAL MEDIADA POR LUZ VISIBLE/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108624RB-I00/ES/HERRAMIENTAS BASADAS EN METALES PARA SU USO EN QUIMICA BIOLOGICA Y BIOMEDICINA. DESARROLLO DE NUEVAS ESTRATEGIAS ANTICANCER/es_ES
dc.rights© 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.es_ES
dc.rightsAtribución 4.0 Internacional
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAzideses_ES
dc.subjectIndoleses_ES
dc.subjectIrradiationes_ES
dc.subjectLightes_ES
dc.subjectPhotocatalystses_ES
dc.titleIntracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysises_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication19c3a725-6287-4e8e-9e5d-e2285f92a721
relation.isAuthorOfPublicationc50c2bff-089c-4f2b-865d-87d093c6db4a
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery19c3a725-6287-4e8e-9e5d-e2285f92a721

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