Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis
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American Chemical Society
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Abstract
Performing abiotic synthetic transformations in live cell environments represents a new, promising approach to interrogate and manipulate biology and to uncover new types of biomedical tools. We now found that photocatalytic bond-forming reactions can be added to the toolbox of bioorthogonal synthetic chemistry. Specifically, we demonstrate that exogenous styryl aryl azides can be converted into indoles inside living mammalian cells under photocatalytic conditions.
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J. Am. Chem. Soc. 2024, 146, 5, 2895–2900
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We are thankful for the financial support of Spanish grants: RYC2020-029150-I and “ESF Investing in your future”, RTI2018-093813-J-I00, PID2019-108624RB-I00, and PID2022-137318OB-I00, funded by MCIN/AEI and by “ERDF A way of making Europe”. We also thank MCIN/ISCIII and the “European Union Next Generation EU/PRTR” (Grant IHRC22-00009), the ORFEO–CINQA network (RED2022-134287-T), the Consellería de Cultura, Educación e Ordenación Universitaria (Grant ED431C 2021/25 and Grant ED431G 2019/03: Centro Singular de Investigación de Galicia accreditation 2019-2022), and the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014-2020). Figures have been created with https://BioRender.com.
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© 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.
Atribución 4.0 Internacional
Atribución 4.0 Internacional