Aniserp: a new serpin from the parasite Anisakis simplex

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URI: http://hdl.handle.net/10347/21698
ISSN: 1756-3305
DOI: 10.1186/s13071-015-1006-z

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2015

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BioMed Central
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Abstract

Serine proteinase inhibitors (serpins) finely regulate serine proteinase activity via a suicide substrate-like inhibitory mechanism. In parasitic nematodes, some serpins interact with host physiological processes; however, little is known about these essential molecules in Anisakis. This article reports the gene sequencing, cloning, expression and preliminary biochemical and bioinformatically-based structural characterization of a new Anisakis serpin (ANISERP)

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Serpin| Proteinase| Anisakis| Trypsin| Thrombin| Cathepsin L| Anticoagulant properties| Modelling analysis| Heparin

Bibliographic citation

Valdivieso, E., Perteguer, M.J., Hurtado, C. et al. ANISERP: a new serpin from the parasite Anisakis simplex . Parasites Vectors 8, 399 (2015). https://doi.org/10.1186/s13071-015-1006-z

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This work was funded by the Spanish Ministry of Science and Innovation (SAF2002-04057-CO2-01) and the Instituto de Salud Carlos III (ISCIII) as part of project MPY 1404/09, and ISCIII-AESI project MPY 1279/15. Carolina Hurtado and Pamela Campioli were supported by grants from the ISCIII (Fondo de InvestigacionesSanitarias), through VI NP of I + D + I (2008–2011), ISCIII- General Sub-Direction of Networks and Centers for Collaborative Research (RETIC-RICET, RD06/0021/0019, RD12/0018/011). Victoria Martínez Sernández holds a predoctoral fellowship from the Spanish Ministerio de Educación, Cultura y Deporte (Programa de Formación del Profesorado Universitario)

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© 2015 Valdivieso et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

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Microbioloxía e Parasitoloxía