Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers
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ISSN: 1433-7851
E-ISSN: 1521-3773
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Abstract
Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with UV light by using a photolabile linker between the acidic tail and the DNA binding peptide
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This is the peer reviewed version of the following article: Jiménez‐Balsa, A. , Pazos, E. , Martínez‐Albardonedo, B. , Mascareñas, J. L. and Vázquez, M. E. (2012), Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers. Angew. Chem. Int. Ed., 51: 8825-8829, which has been published in final form at https://doi.org/10.1002/anie.201201627. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
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Jiménez‐Balsa, A., Pazos, E., Martínez‐Albardonedo, B., Mascareñas, J. L. and Vázquez, M. E. (2012), Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers. Angew. Chem. Int. Ed., 51: 8825-8829. doi:10.1002/anie.201201627
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https://doi.org/10.1002/anie.201201627Sponsors
Consolider Ingenio. Grant Numbers: SAF2010‐20822‐C02, CTQ2009‐14431/BQU, CSD2007‐00006
Xunta de Galicia. Grant Numbers: INCITE09 209 084PR, PGIDIT08CSA‐047209PR, GRC2010/12
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© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions