New sequence variants in HLA Class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicinagl
dc.contributor.authorNakajima, Masahiro
dc.contributor.authorTakahashi, Atsushi
dc.contributor.authorKou, Ikuyo
dc.contributor.authorRodríguez Fontenla, María Cristina
dc.contributor.authorGómez-Reino Carnota, Juan Jesús
dc.contributor.authorFuruichi, Tatsuya
dc.contributor.authorDai, Jin
dc.contributor.authorSudo, Akihiro
dc.contributor.authorUchida, Atsumasa
dc.contributor.authorFukui, Naoshi
dc.contributor.authorKubo, Michiaki
dc.contributor.authorKamatani, Naoyuki
dc.contributor.authorTsunoda, Tatsuhiko
dc.contributor.authorMalizos, Konstantinos N.
dc.contributor.authorTsezou, Aspasia
dc.contributor.authorGonzález Martínez-Pedrayo, Antonio
dc.contributor.authorNakamura, Yusuke
dc.contributor.authorIkegawa, Shiro
dc.date.accessioned2020-06-06T09:04:14Z
dc.date.available2020-06-06T09:04:14Z
dc.date.issued2010
dc.description.abstractOsteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10−8 for rs7775228 and 6.73×10−8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OAgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThe Japanese study is supported by the Leading Project for Personalized Medicine in the Ministry of Education, Culture, Sports, Science and Technology. The European study is supported by Instituto de Salud Carlos III from the Spanish Health Ministry with participation of FEDER (Fondo Europeo para el Desarrollo Regional), the Foundation Mutua Madrile (Madrid)gl
dc.identifier.citationNakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino JJ, Furuichi T, et al. (2010) New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study. PLoS ONE 5(3): e9723. https://doi.org/10.1371/journal.pone.0009723gl
dc.identifier.doi10.1371/journal.pone.0009723
dc.identifier.essn1932-6203
dc.identifier.urihttp://hdl.handle.net/10347/22836
dc.language.isoenggl
dc.publisherPlosgl
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0009723gl
dc.rights© 2010 Nakajima et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedgl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectOsteoarthritisgl
dc.subjectKnee Osteoarthritisgl
dc.subjectGenome-wide identificationgl
dc.subjectHLA Class II/IIIgl
dc.titleNew sequence variants in HLA Class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association studygl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication

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