FNDC5 is produced in the stomach and associated to body composition

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicasgl
dc.contributor.authorBarja Fernández, Silvia
dc.contributor.authorFolgueira Cobos, Cintia
dc.contributor.authorCastelao Taboada, Cecilia
dc.contributor.authorBravo López, Susana Belén
dc.contributor.authorGarcía-Caballero Parada, Tomás
dc.contributor.authorLeis Trabazo, María Rosaura
dc.contributor.authorPardo Pérez, María
dc.contributor.authorCasanueva Freijo, Felipe
dc.contributor.authorSeoane Camino, Luisa María
dc.date.accessioned2017-10-21T12:52:22Z
dc.date.available2017-10-21T12:52:22Z
dc.date.issued2016-03-10
dc.description.abstractThe fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expression of FNDC5 in the rat stomach and its potential regulation by body composition. The present data shows FNDC5 gene expression in the gastric mucosa. Immunohistochemical studies found FNDC5 immunopositivity in chief cells of gastric tissue. By the use of three different antibodies FNDC5 was found expressed in gastric mucosa and secreted by the stomach. The rate of gastric FNDC5 secretion parallels the circulating levels of FNDC5. The body fat mass increase after intervention with high fat diet coincided with a decrease in the secretion of FNDC5 from the stomach and a diminution in the FNDC5 circulating levels. In summary, the present data shows, for the first time, the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasisgl
dc.description.peerreviewedSIgl
dc.description.sponsorshiphis work has been supported by grants from Instituto de Salud Carlos III (PI1202021 and PI15/01272) cofounded by FEDER, Xunta de Galicia (10 PXIB 918 273PR) and Fundación Mutua Madrileña. SB-F is funded by Xunta de Galicia and Universidade de Santiago de Compostela, CF by IDIS (Instituto de Investigación Sanitaria de Santiago de Compostela), CC by Ciber obn and OA-M is funded by the ISCIII/SERGAS thought a research contract “Sara Borrell” (CD14/00091). MP is funded by ISCIII/SERGAS through a research contract “Miguel Servet II”. LMS is a SERGAS-I3SNS researcher. Centro de Investigacion Biomedica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn) is a iniciative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER fundsgl
dc.identifier.citationBarja-Fernández, S. et al. FNDC5 is produced in the stomach and associated to body composition. Sci. Rep. 6, 23067; doi: 10.1038/srep23067 (2016)gl
dc.identifier.doi10.1038/srep23067
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10347/15967
dc.language.isoenggl
dc.publisherNature Publishing Groupgl
dc.relation.publisherversionhttps://doi.org/10.1038/srep23067gl
dc.rights© The Author(s) 2016.This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/gl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subjectHomeostasisgl
dc.subjectObesitygl
dc.titleFNDC5 is produced in the stomach and associated to body compositiongl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublicationf825b64a-9678-43c6-8c1d-6a943ec91adb
relation.isAuthorOfPublication1e3d57c2-ad35-4203-8ea0-f72f75021208
relation.isAuthorOfPublication97168138-a5c3-44f4-b4ea-71e3ef68a1bf
relation.isAuthorOfPublication.latestForDiscoveryf825b64a-9678-43c6-8c1d-6a943ec91adb

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