Polypeptide and polyphozphazene based nanosystems for anticancer gene therapy

Abstract

Glioblastoma and uveal melanoma are tumors without very high incidence rate, but they are characterized by being one of the most aggressive tumors with a life expectancy between 6 and 14 months. Their standard treatment is based on surgical resection followed by radiotherapy and chemotherapy triggering several severe side effects. Consequently, the search for new therapeutic approaches is required, where gene therapy stands out. However, genetic medicines require delivery systems for the protection and transport of nucleic acids to target cancer cells. In this field, nanomedicine plays an important role to the design of polymeric non-viral vectors, being very promising in gene therapy. The present work is focused on the development of tunable gene delivery nanosystems and their evaluation in different advanced preclinical cancer models.