RT Dissertation/Thesis
T1 Polypeptide and polyphozphazene based nanosystems for anticancer gene therapy
A1 Barrios Esteban, Sheila
K1 Nanoparticles
K1 polymeric
K1 gene-delivery
K1 glioblastoma
K1 uveal melanoma
AB Glioblastoma and uveal melanoma are tumors without very high incidencerate, but they are characterized by being one of the most aggressive tumors with a life expectancy between 6 and14 months. Their standard treatment is based on surgical resection followed by radiotherapy and chemotherapytriggering several severe side effects. Consequently, the search for new therapeutic approaches is required, wheregene therapy stands out. However, genetic medicines require delivery systems for the protection and transport ofnucleic acids to target cancer cells. In this field, nanomedicine plays an important role to the design of polymericnon-viral vectors, being very promising in gene therapy. The present work is focused on the development of tunablegene delivery nanosystems and their evaluation in different advanced preclinical cancer models.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30417
UL http://hdl.handle.net/10347/30417
LA eng
DS Minerva
RD 4 may 2026