Rh(III)-catalyzed annulations based on C-H activation. Sustainable synthesis of carbo- and heterocycles

Abstract

One of the main challenges still present within organic synthesis is the ability to achieve complex molecules with high efficiency. In this context metal-catalyzed C-H functionalization processes have gained a lot of attraction due to their ability to increase molecular complexity in few steps and with a minimum generation of waste. These kind of reactions occurs through a metallacyclic intermediate which can be trapped with a huge variety of unsaturated products by a cycloaddition step. This combination of C-H activation and cycloaddition allows to obtain cyclic structures in few steps and high yields. The work realized within my PhD period embraces the field of C-H activation through the development of novel reactivity patterns in Rhodium (III)-catalyzed oxidative annulation reactions. These processes allow to obtain interseting biological and/or biomedic compounds with a high atom and step economy from simple comercial precursors.