Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicinagl
dc.contributor.authorRodrigues Amorim, Daniela
dc.contributor.authorRivera Baltanás, Tania
dc.contributor.authorVallejo Curto, María del Carmen
dc.contributor.authorRodríguez Jamardo, Cynthia
dc.contributor.authorHeras, Elena de las
dc.contributor.authorBarreiro Villar, Carolina
dc.contributor.authorBlanco Formoso, María
dc.contributor.authorFernández Palleiro, Patricia
dc.contributor.authorÁlvarez Ariza, María
dc.contributor.authorLópez García, Marta
dc.contributor.authorGarcía Caballero, Alejandro Alberto
dc.contributor.authorOlivares Díez, José Manuel
dc.contributor.authorSpuch, Carlos
dc.date.accessioned2020-04-07T16:20:29Z
dc.date.available2020-04-07T16:20:29Z
dc.date.issued2019
dc.description.abstractSchizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF- β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia.gl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work was financially backed by the Foundation for Science and Technology (FCT, Fundação para a Ciência e Tecnologia) within the framework of grant SFRH/BD/135623/2018 awarded to Daniela Rodrigues- Amorim, and another grant of Fundación Tatiana Pérez de Guzmanel Bueno provided to Carlos Spuch. Our research was further supported by the Carlos III Health Institute (ISCIII, Instituto Carlos III) through grant P16/00405 and co-funding awarded by the Spanish Foundation of Rare Diseases (FEDER, Fundación Española de Enfermedades Raras) to José Manuel Olivaresgl
dc.identifier.citationRodrigues-Amorim D, Rivera-Baltanás T, Vallejo-Curto MdC, Rodriguez-Jamardo C, de las Heras E, Barreiro-Villar C, Blanco-Formoso M, Fernández-Palleiro P, Álvarez-Ariza M, López M, García-Caballero A, Olivares JM and Spuch C (2019) Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways. Front. Psychiatry 10:885. doi: 10.3389/fpsyt.2019.00885gl
dc.identifier.doi10.3389/fpsyt.2019.00885
dc.identifier.essn1664-0640
dc.identifier.urihttp://hdl.handle.net/10347/21228
dc.language.isoenggl
dc.publisherFrontiers Mediagl
dc.relation.publisherversionhttps://doi.org/10.3389/fpsyt.2019.00885gl
dc.rightsCopyright © 2019 Rodrigues-Amorim, Rivera-Baltanás, Vallejo-Curto, Rodriguez- Jamardo, de las Heras, Barreiro-Villar, Blanco-Formoso, Fernández-Palleiro, Álvarez- Ariza, López, García-Caballero, Olivares and Spuch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termsgl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSchizophreniagl
dc.subjectProteomicsgl
dc.subjectLiquid chromatography–tandem mass spectrometrygl
dc.subjectRab3 GTPaseactivating protein catalytic subunitgl
dc.subjectGlia maturation factor betagl
dc.subjectBrain-derived neurotrophic factorgl
dc.titleProteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathwaysgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication

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