Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2014-12-05T13:26:23Z
dc.date.available2017-08-29T01:00:16Z
dc.date.issued2014-04-24
dc.description.abstractWe report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein failed to bind to DNA; however, modifications that increased the α-helical folding propensity of the peptide allowed specific DNA binding by a bipartite (major/minor groove) interactiongl
dc.description.peerreviewedSIgl
dc.description.sponsorshipMinisterio de Economía y Competitividad. Grant Numbers: SAF2010-20822-C02, CTQ2012-31341 Consolider Ingenio. Grant Number: 2010 CSD2007-00006 Xunta de Galicia. Grant Number: GRC2013/14 European Regional Development Fund European Research Council. Grant Number: Na 340055 Ministerio de Ciencia e Innovación Fundación Gil Dávilagl
dc.identifier.citationMosquera, J., Rodríguez, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras. ChemBioChem, 15: 1092–1095. doi: 10.1002/cbic.201400079gl
dc.identifier.doi10.1002/cbic.201400079
dc.identifier.issn1439-7633
dc.identifier.urihttp://hdl.handle.net/10347/11967
dc.language.isoenggl
dc.publisherWILEY-VCH Verlag GmbHgl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.publisherversionhttp://dx.doi.org/10.1002/cbic.201400079gl
dc.rights© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimgl
dc.rights.accessRightsopen accessgl
dc.subjectDNA recognitiongl
dc.subjectMolecular recognitiongl
dc.subjectOligonucleotidesgl
dc.subjectPeptidesgl
dc.subjectSupramolecular chemistrygl
dc.subject.classificationMaterias::Investigación::23 Química::2302 Bioquímicagl
dc.titleSelective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimerasgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
relation.isAuthorOfPublication1b4c7a3c-215b-42bf-9ce2-c533031318dc
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery1b4c7a3c-215b-42bf-9ce2-c533031318dc

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