Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéuticagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
dc.contributor.authorDunster, Joanne L.
dc.contributor.authorUnsworth, Amanda J.
dc.contributor.authorBye, Alexander P.
dc.contributor.authorHaining, Elizabeth J.
dc.contributor.authorSowa, Marcin A.
dc.contributor.authorDi, Ying
dc.contributor.authorSage, Tanya
dc.contributor.authorPallin, Chiara
dc.contributor.authorPike, Jeremy A.
dc.contributor.authorHardy, Alexander T.
dc.contributor.authorNieswandt, Bernhard
dc.contributor.authorGarcía Alonso, Ángel
dc.contributor.authorWatson, Steve P.
dc.contributor.authorPoulter, Natalie S.
dc.contributor.authorGibbins, Jonathan M.
dc.contributor.authorPollitt, Alice Y.
dc.date.accessioned2020-04-07T18:19:28Z
dc.date.available2020-04-07T18:19:28Z
dc.date.issued2019
dc.description.abstractAccurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of subcellular interactions and as part of the drug discovery process. Quantitative proteomics, flow cytometry, and western blotting have been extensively used to define human platelet protein copy numbers, yet for mouse platelets, a model widely used for platelet research, evidence is largely limited to a single proteomic dataset in which the total amount of proteins was generally comparatively higher than those found in human platelets.gl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work was supported by the Academy of Medical Science springboard grant to A.Y.P. [SBF002\1099]. The support of the British Heart Foundation (BHF) is gratefully acknowledged by J.L.D., (PG/16/20/32074) T.S., A.P.B and A.J.U (RG/15/2/31224) to J.M.G. B.N. is supported by the Deutsche Forschungsgemeinschaft (grant SFB/TR 240). The mouse model was generated with support from the BHF (FS/15/71/31677). E.J.H. was supported by a BHF grant (RG/13/18/30563) to S.P.W. who holds a BHF (CH0/003) supporting Y.D and N.S.P. M.S. is supported by a European Union’s Horizon 2020 research and innovation program under Marie Sklodowska‐Curie grant agreement No. 766118 to S.P.W., N.S.P., A.Y.P., J.M.G., B.N., and A.Ggl
dc.identifier.citationDunster, JL, Unsworth, AJ, Bye, AP, et al. Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. J Thromb Haemost. 2020; 18: 485– 496. https://doi.org/10.1111/jth.14673gl
dc.identifier.doi10.1111/jth.14673
dc.identifier.essn1538-7836
dc.identifier.issn1538-7933
dc.identifier.urihttp://hdl.handle.net/10347/21240
dc.language.isoenggl
dc.publisherWileygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/766118
dc.relation.publisherversionhttps://doi.org/10.1111/jth.14673gl
dc.rights© 2019 The Authors and the Journal of Thrombosis and Haemostasis. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly citedgl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGPVIgl
dc.subjectMathematical modellinggl
dc.subjectPlateletgl
dc.subjectSykgl
dc.titleInterspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activationgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublicationed66fc62-58f0-4068-bd27-907f9137e112
relation.isAuthorOfPublication.latestForDiscoveryed66fc62-58f0-4068-bd27-907f9137e112

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