Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones

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2012_orglett_villarino_palladium.pdf (353.46 KB)
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URI: http://hdl.handle.net/10347/18477
ISSN: 1523-7060
E-ISSN: 1523-7052
DOI: 10.1021/ol300988n

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2012

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American Chemical Society
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Abstract

A practical protocol for the hydroalkynylation of enones using Pd catalysis is reported. The reaction proceeds efficiently with a variety of alkynes as well as with several cyclic and acyclic enones, providing synthetically relevant β-alkynyl ketones in good to excellent yields

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This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/ol300988n

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Villarino, L., García-Fandiño, R., López, F., & Mascareñas, J. (2012). Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones. Org. Lett., 14, 12, 2996-2999. DOI: 10.1021/ol300988n

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This work was supported by the Spanish MINECO [SAF2007-61015, SAF2010-20822-C02, Consolider Ingenio 2010 CSD2007-00006], the ERDF and the Xunta de Galicia INCITE09209084PR, GRC2010/12. L.V. and R.G.-F. thank the Spanish MEC and MINECO for an FPU fellowship and a Juan de la Cierva contract, respectively

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© 2012 American Chemical Society

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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica