Alonso Fernández, María JoséCrecente Campo, JoséGómez Dacoba, Tamara2020-09-302020-09-302020http://hdl.handle.net/10347/23326Nanotechnologies with the ability to modulate the immune system can be exploited to develop new advanced therapies. The first part of this thesis describes a potential HIV vaccine candidate consisting of nanoparticles loaded with up to three peptide antigens. Based on the good responses in terms of protection against viral infection in macaques, the quality-by-design and scaling-up production of this vaccine candidate was performed. Finally, in the context of cancer, a potential immunotherapy with the capacity to polarize tumor-associated macrophages towards anti-tumoral phenotypes was developed.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/HIV vaccineCancer immunotherapyNanotechnologyMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosMaterias::Investigación::24 Ciencias de la vida::2412 Inmunología::241210 Vacunasdoctoral thesisopen access