Sánchez López, Mateo IsidroVázquez Vázquez, OlallaMartínez Costas, José ManuelVázquez Sentís, Marco EugenioMascareñas Cid, José Luis2019-03-272019-03-272012Sánchez, M., Vázquez, O., Martínez-Costas, J., Vázquez, M., & Mascareñas, J. (2012). Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes. Chem. Sci., 3, 2383-2387. doi: 10.1039/c2sc00027jhttp://hdl.handle.net/10347/18489Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these molecules. One of them, the azide-aza-bisbenzamidine 13, can be readily modified via click-chemistry with a variety of functionalities that can, therefore, be delivered to the vicinity of an A/T-rich DNA minor groove. This strategy, therefore, provides a simple means for triggering site selective, DNA-promoted biochemical and physicochemical processeseng© The Royal Society of Chemistry 2012journal article10.1039/C2SC00027J2041-6539open access